Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

letter

. 2014 Dec 13;2:166. doi: 10.1186/s40478-014-0166-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Hukema et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Expression of 80GGGGCC-repeats leads to the formation of ubiquitin-positive inclusions in mouse brain. A) Schematic of the model used to create the inducible mice. Simultaneous expression of rtTA and doxycycline treatment are needed to drive expression of the TRE-80GGGGCC-eGFP construct. PCR for determining repeat size in three transgenic mice containing the repeat construct. B) GFP expression in the striatum of bigenic mice after 12 weeks dox treatment. C) Intranuclear (arrows) and neuropil (arrowheads) ubiquitin-positive inclusionsin the striatum of bigenic mice after 12 weeks dox treatment.