Table 5.
Prenatal exposure to bisphenol A (quartiles) and odds low (≤10th percentile) and high (≥90th percentile) cord blood adipokines, overall and by sex
| Low leptin a | High leptin a | |||
|---|---|---|---|---|
| Contaminant | Unadjusted OR | Adjusted OR b | Unadjusted OR | Adjusted OR b |
| (95% CI) | (95% CI) | (95% CI) | (95% CI) | |
| BPA | ||||
| Total (n =1165) | ||||
| ≤0.34 | 1.0 | 1.0 | 1.0 | 1.0 |
| 0.35- ≤ 0.81 | 1.2 (0.7-2.0) | 1.3 (0.8-2.3) | 0.9 (0.5-1.5) | 0.9 (0.5-1.6) |
| 0.82- ≤ 1.7 | 1.1 (0.6-1.8) | 1.3 (0.7-2.5) | 1.2 (0.7-2.0) | 1.1 (0.6-2.0) |
| >1.7 | 0.9 (0.5-1.6) | 1.3 (0.7-2.6) | 1.1 (0.6-1.8) | 0.9 (0.5-1.8) |
| Males (n =626) | ||||
| ≤0.34 | 1.0 | 1.0 | 1.0 | 1.0 |
| 0.35- ≤ 0.81 | 0.9 (0.4-2.0) | 1.0 (0.5-2.3) | 1.1 (0.5-2.3) | 1.0 (0.5-2.3) |
| 0.82- ≤ 1.7 | 1.0 (0.5-2.0) | 1.1 (0.5-2.6) | 1.2 (0.6-2.6) | 1.2 (0.5-2.9) |
| >1.7 | 0.8 (0.4-1.6) | 1.0 (0.4-2.4) | 1.2 (0.6-2.4) | 1.0 (0.4-2.4) |
| Females (n =539) | ||||
| ≤0.34 | 1.0 | 1.0 | 1.0 | 1.0 |
| 0.35- ≤ 0.81 | 1.6 (0.3-1.6) | 1.8 (0.8-4.1) | 0.7 (0.3-1.6) | 0.7 (0.3-1.6) |
| 0.82- ≤ 1.7 | 1.2 (0.5-2.8) | 1.6 (0.6-4.4) | 1.1 (0.5-2.3) | 1.0 (0.4-2.4) |
| >1.7 | 1.1 (0.5-2.7) | 1.8 (0.6-5.1) | 1.0 (0.5-2.2) | 0.8 (0.3-2.2) |
| Low adiponectin a | High adiponectin a | |||
| Unadjusted OR | Adjusted OR c | Unadjusted OR | Adjusted OR c | |
| (95% CI) | (95% CI) | (95% CI) | (95% CI) | |
| BPA | ||||
| Total (n =1232) | ||||
| ≤0.34 | 1.0 | 1.0 | 1.0 | 1.0 |
| 0.35- ≤ 0.81 | 0.8 (0.5-1.4) | 0.9 (0.5-1.5) | 0.7 (0.4-1.2) | 0.8 (0.5-1.4) |
| 0.82- ≤ 1.7 | 0.7 (0.4-1.3) | 0.8 (0.4-1.4) | 0.7 (0.4-1.1) | 1.0 (0.5-1.8) |
| >1.7 | 0.8 (0.5-1.4) | 0.9 (0.4-1.6) | 0.6 (0.4-1.1) | 1.0 (0.5-1.9) |
| Males (n =660) | ||||
| ≤0.34 | 1.0 | 1.0 | 1.0 | 1.0 |
| 0.35- ≤ 0.81 | 0.9 (0.4-1.8) | 0.9 (0.4-1.9) | 0.6 (0.3-1.3) | 0.8 (0.3-1.6) |
| 0.82- ≤ 1.7 | 0.7 (0.3-1.5) | 0.7 (0.3-1.7) | 0.3 (0.1-0.8) | 0.5 (0.2-1.2) |
| >1.7 | 0.8 (0.4-1.7) | 0.8 (0.3-2.0) | 0.8 (0.4-1.7) | 0.9 (0.4-2.2) |
| Females (n =572) | ||||
| ≤0.34 | 1.0 | 1.0 | 1.0 | 1.0 |
| 0.35- ≤ 0.81 | 0.8 (0.4-1.7) | 0.9 (0.4-1.9) | 0.8 (0.4-1.6) | 0.9 (0.4-1.9) |
| 0.82- ≤ 1.7 | 0.8 (0.3-1.6) | 0.8 (0.3-2.0) | 1.1 (0.6-2.3) | 1.7 (0.8-3.8) |
| >1.7 | 0.8 (0.4-1.7) | 0.9 (0.3-2.2) | 0.7 (0.3-1.5) | 1.1 (0.5-2.8) |
aModerate adipokine levels (10-90th percentile) represent those without the outcome.
bAdjusted for: maternal age, pre-pregnancy BMI, specific gravity, parity.
cAdjusted for: maternal age, specific gravity, education.