Fig. 2.

Hsp90 client status dynamics across the kinome. (a) Using the three client classes defined by Taipale et al. (2012), we categorized pairs of duplicated genes into six classes. We find that gene duplicates share client status (χ²-test, P = 1.837e-05) more often than expected by chance. The number of expected pairs was calculated based a random distribution of clients across the tree. (b) Kinases (white) are three times more likely to gain Hsp90 client status (red) than lose it based on ML and MCMC estimates of state transition rates using Bayes Traits.