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A fluorescence readout directly reporting RNR-α hexamerization. Feedback inhibitor dATP binding at the A site induces assembly of α6 states in which the donor fluorescein signal is quenched. Gray and dark spheres are fluorescein (F)- and tetramethylrhodamine (T)-labeled α monomers. Hexamers with all T-α are omitted for clarity. The ribbon represents the known 6.6 Å crystal structure of dATP-bound α6 from S. cerevisiae (3PAW).
