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. Author manuscript; available in PMC: 2014 Dec 19.
Published in final edited form as: Toxicol Appl Pharmacol. 2010 Mar 28;245(3):344–351. doi: 10.1016/j.taap.2010.03.020

Fig. 7.

Fig. 7

Effect of As+3 co-treatment with DMBA-diol on the primary spleen cell humoral immune (IgM) response to SRBC examined in vitro. Spleen cells were immunized in vitro at the same time of treatment with As+3 (0.5 or 5 µM in H2O) and/or DMBA-diol (0.001 – 1 µM in DMSO). No cytotoxicity was observed in these cultures. Data from a pool of three mouse spleens that were assayed in quadruplicate are shown as mean ± S.E.M. *indicates a statistically significant effect of As+3 or PAHs compared to water control for As+3 or DMSO control for PAHs (p < 0.05). #indicates the synergistic interaction between As+3 and PAH as the suppression is greater than an additive effect.