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. 2014 Dec 16;5(6):e02249-14. doi: 10.1128/mBio.02249-14

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Copyright © 2014 Koyuncu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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FIG 4 — Sirtuin-modulating drugs impact influenza virus H1N1 virus replication. (A) EX-527 enhances influenza A virus replication. MDCK cells were infected with influenza A virus PR8 (0.001 TCID₅₀/cell) and treated with EX-527 at 1 hpi. Virus yield was determined at 24 hpi. (B) Resveratrol inhibits influenza A virus replication. MDCK cells were infected with PR8 (0.1 TCID₅₀/cell) and treated with resveratrol (50 µM) at 1 hpi. Virus yields were determined as for panel A. MDCK cells were treated with sirtuin modulators or DMSO for 24 h. Cell viability was assessed using a colorimetric tetrazolium reduction assay. For all experiments: **, P < 0.01; *, P < 0.05.