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Schematic representation of the crystal structure of ERAP1 (PDB code: 3MDJ). The amino acids at the sites of polymorphic variation that have been found to either affect enzyme function or to associate with pre-disposition to cancer are indicated by green spheres. The catalytic Zn(II) atom at active site of the enzyme is shown by a red sphere. Note that the polymorphic sites are distal to the active site and distributed throughout the enzyme.
