Table 1.
Most common ERAP1 and ERAP2 SNPs, relation to disease, HLA, and functional consequences.
| ERAP1/2 SNP | Disease association | HLA class I link | Affects | |
|---|---|---|---|---|
| ERAP1 | rs3734016 (E56K) | HPV-induced cervical carcinoma | Expression levels | |
| rs26653 (R127P) | Ankylosing spondylitis, HPV-induced cervical carcinoma | Expression levels | ||
| rs2287987 (M349V) | Ankylosing spondylitis | |||
| rs30187 (K528R) | Ankylosing spondylitis, psoriasis, essential hypertension, multiple sclerosis | B*27 Cw*0602 | Activity and specificity | |
| rs10050860 (D575N) | Ankylosing spondylitis, Behçet disease | Activity | ||
| rs17482078 (R725Q) | Ankylosing Spondylitis, Behçet disease | B*51 | Activity | |
| rs27044 (Q730E) | Ankylosing spondylitis, HPV-induced cervical carcinoma | Activity and specificity | ||
| ERAP2 | rs2549782 (K392N) | Ankylosing spondylitis, preeclampsia, resistance to HIV infection | Activity and specificity | |
| rs2248374 (non-coding) | Ankylosing spondylitis | Expression levels |