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. 2014 Dec 19;5:499. doi: 10.3389/fphys.2014.00499

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Copyright © 2014 Berg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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An overview of the experimental design to test the role of β₃AR in catecholamine release. The presynaptic βAR will be activated by the released norepinephrine or by circulating epinephrine from the adrenals. Dotted arrows; tested, but not verified hypothesis. ^*; effect observed in SHR only in response to β₃AR antagonist (adrenal) and antagonist (neuronal). NE, norepinephrine; E, epinephrine; NET, norepinephrine re-uptake transporter.