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. 2014 Jun 27;66(7):1832–1842. doi: 10.1002/art.38616

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© 2014 The Authors. Arthritis & Rheumatology is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Pain behavior in STR/Ort and CBA mice does not show significant variation with age. Paw pressure (A), cold sensitivity (B), mechanical allodynia (von Frey filaments) (C), and number of vocalizations following knee compression (D) were each measured once a month in the left and right hind limbs of CBA and STR/Ort mice, from 16 weeks to 36 weeks of age. No significant changes with time were identified in either strain. (In contrast, typical values for hypersensitivity in a study of surgically induced osteoarthritis in mice [20] were as follows: paw pressure 60–70g, cold sensitivity 5–7 seconds, mechanical allodynia [von Frey filaments] 0.1–0.2g, and vocalizations 2.5–3.) Values are the mean ± SEM.