Table 4.
Factors associated with mortality, as determined by multivariate analysis*
| No. of patients still living (n = 101) | No. of patients deceased (n = 15) | Mortality rate, % | P (OR [95% CI]) | |
|---|---|---|---|---|
| Age, years | NS | |||
| <60 | 80 | 11 | 12.1 | |
| ≥60 | 21 | 4 | 16 | |
| Sex | <0.01 (6.47 [2.06–30.39]) | |||
| Male | 19 | 9 | 32.1 | |
| Female | 82 | 6 | 6.8 | |
| Underlying disease | ||||
| SLE | 55 | 6 | 9.8 | NS |
| AOSD | 28 | 3 | 9.7 | NS |
| Dermatomyositis | 4 | 4 | 50 | <0.05 (5.57 [1.08–28.65]) |
| Rheumatoid arthritis | 5 | 0 | 0 | NS |
| Evans' syndrome | 4 | 0 | 0 | NS |
| Sarcoidosis | 1 | 1 | 50 | NS |
| Systemic sclerosis | 0 | 1 | 100 | NS |
| Mixed connective tissue disease | 1 | 0 | 0 | NS |
| Vasculitis syndrome | 1 | 0 | 0 | NS |
| Sjögren's syndrome | 1 | 0 | 0 | NS |
| Ankylosing spondylitis | 1 | 0 | 0 | NS |
| Physical findings† | ||||
| Body temperature | NS | |||
| <37.5°C | 14 | 1 | 6.7 | |
| ≥37.5°C | 85 | 14 | 14.1 | |
| Lymphadenopathy | NS | |||
| Present | 27 | 5 | 15.6 | |
| Absent | 42 | 4 | 8.7 | |
| Hepatomegaly | NS | |||
| Present | 20 | 8 | 28.6 | |
| Absent | 35 | 4 | 10.3 | |
| Splenomegaly | NS | |||
| Present | 34 | 6 | 15 | |
| Absent | 43 | 5 | 10.4 | |
| Laboratory findings† | ||||
| WBC count, ×109/liter | NS | |||
| <2 | 33 | 5 | 13.2 | |
| ≥2 | 61 | 6 | 9 | |
| Hgb, gm/dl | <0.05 (3.74 [1.02–13.80]) | |||
| <8 | 28 | 8 | 22.2 | |
| ≥8 | 66 | 5 | 7 | |
| Platelet count, ×109/liter | NS | |||
| <50 | 24 | 6 | 20 | |
| ≥50 | 76 | 9 | 10.6 | |
| Coagulopathy | NS | |||
| Present | 33 | 7 | 17.5 | |
| Absent | 36 | 3 | 7.7 | |
| AST, IU/liter | NS | |||
| <100 | 44 | 6 | 12 | |
| ≥100 | 34 | 4 | 10.5 | |
| ALT, IU/liter | NS | |||
| <100 | 35 | 6 | 14.6 | |
| ≥100 | 20 | 3 | 13 | |
| LDH, IU/liter | NS | |||
| <500 | 23 | 2 | 8 | |
| ≥500 | 54 | 7 | 11.5 | |
| CRP, mg/dl | NS | |||
| <2 | 33 | 1 | 2.9 | |
| ≥2 | 44 | 6 | 12 | |
| <10 | 56 | 3 | 5.1 | |
| ≥10 | 21 | 4 | 16 | |
| Ferritin, μg/liter | NS | |||
| <500 | 20 | 2 | 9.1 | |
| ≥500 | 65 | 10 | 13.3 | |
| <10,000 | 60 | 9 | 13 | |
| ≥10,000 | 25 | 3 | 10.7 |
*
OR = odds ratio; 95% CI = 95% confidence interval; NS = not significant; SLE = systemic lupus erythematosus; AOSD = adult-onset Still's disease; WBC = white blood cell; Hgb = hemoglobin; AST = aspartate aminotransferase; ALT = alanine aminotransferase; LDH = lactate dehydrogenase; CRP = C-reactive protein.
†
Data not available on all patients.