Skip to main content
. 2014 Dec 19;5:650. doi: 10.3389/fimmu.2014.00650

Figure 6.

Figure 6

Vδ2 T cells have distinct adjuvant effects for DC and B cells. Co-cultures of Vδ2 T cells with either DC or B cells produce IL-6 and TNF-α, but not IL-12 nor IL-10. However, Vδ2 T cells induce IFN-γ production and co-stimulatory marker expression by DC after 24 h and these matured DC induce proliferation of alloreactive T cells, which then secrete IFN-γ. In contrast, Vδ2 T cells induce IL-4 production and co-stimulatory molecule expression by B cells after 72 h and immunoglobulin secretion after 7 days. These matured B cells induce proliferation but not IFN-γ, IL-2, IL-4 nor IL-10 production by alloreactive T cells.