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Genome-wide CNV burden. These forest plots show OR estimates and 95% confidence intervals for each burden test. The size of the square is proportional to precision. Allele frequency categories: 1x means single-occurrence CNVs observed once in a case or control (MAF < 0.0001). These were conservatively defined as having no overlap with any other CNVs. 2–6x means 2 to 6 occurrences (MAF 0.0001–0.0005). 7x+ means ≥7 occurrences (MAF 0.0005–0.01).
