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. Author manuscript; available in PMC: 2014 Dec 19.
Published in final edited form as: Mol Psychiatry. 2014 Apr 29;19(7):762–773. doi: 10.1038/mp.2014.40

Figure 4.

Figure 4

Relative impact of rare CNV burden and common variant allelic burden. We computed the difference in the Nagelkerke pseudo R2 score to estimate the proportion of variance of case-control status in the Swedish samples accounted for by the common variant allelic burden (risk profile scores, RPS) and by the rare CNV burden (as measured by the number of CNV at known SCZ-associated loci). We examined CNV burden of 1q21.1del, 3q29del, 15p13.3del, 22q11.2del, 16p11.2dup, individually and combined. The Y-axis of the barplot shows the estimates of effect size (i.e. Nagelkerke pseudo R2). RPS accounted for at least an order of magnitude more variance than rare CNVs in this sample.