Table 1.
Sample characteristics | Cases | Controls |
---|---|---|
| ||
Subjects (after quality control) | ||
Sw1 (Affymetrix 5.0) | 207 | 206 |
Sw2–4 (Affymetrix 6.0) | 1,847 | 2,137 |
Sw5–6 (Illumina Omni Express) | 2,665 | 3,574 |
Total sample | 4,719 | 5,917 |
| ||
Male sex | 0.599 | 0.513 |
| ||
Median age at sampling | 54 (45–62) | 57 (48–65) |
| ||
Median hospital admissions for schizophrenia | 6 (3–13) | n/a |
| ||
Median total inpatient days | 239 (79–694) | n/a |
| ||
Median years from first to last admission | 9.7 (2.9–19.5) | n/a |
| ||
Proportion of all CNVs that are deletions | ||
Sw1 | 0.40 | 0.47 |
Sw2–4 | 0.37 | 0.36 |
Sw5–6 | 0.40 | 0.40 |
Total sample | 0.38 | 0.38 |
| ||
Median CNV size | ||
Sw1 | 181.3 | 178.0 |
Sw2–4 | 182.2 | 188.2 |
Sw5–6 | 183.1 | 190.7 |
Total sample | 182.7 | 188.8 |
| ||
Mean number of CNVs per subject | ||
Sw1 | 1.058 | 0.845 |
Sw2–4 | 1.236 | 1.209 |
Sw5–6 | 0.758 | 0.684 |
Total sample | 0.958 | 0.879 |
After quality control, the combined sample size is 10,636, where Sw1=413 (3.9%, Affymetrix 5.0), Sw2–4=3,984 (37.5%, Affymetrix 6.0), and Sw5–6=6,239 (58.7%, Illumina OmniExpress). Values in parentheses are inter-quartile ranges. Cases had significantly more males (p < 0.0001) and were significantly younger (p < 0.0001) than controls although these differences were not of large magnitude. The higher median age in controls is in the direction of greater confidence in control classification (i.e., controls had greater time at risk for psychiatric hospitalization). The mean number of >500Kb CNVs and of singleton CNVs are reported in Table S8.