Table 3.
Predicted NRSF regulation of genes affecting mood.
| Gene | Locus | Strand | NRSF site | Size (Bp) | Position |
|---|---|---|---|---|---|
| ACE | chr17:61554422–61575741 | + | chr17:61553914–61554174 | 260 | −508 |
| ACE | chr17:61554422–61575741 | + | chr17:61554504–61554774 | 270 | 82 |
| ACE | chr17:61554422–61575741 | + | chr17:61556270–61556594 | 324 | 1848 |
| ACE | chr17:61554422–61575741 | + | chr17:61557174–61557444 | 270 | 2752 |
| ACE | chr17:61554422–61575741 | + | chr17:61558309–61558579 | 270 | 3887 |
| ADRBK2 | chr22:25960861–26125258 | + | chr22:25961290–25961560 | 270 | 429 |
| ADRBK2 | chr22:25960861–26125258 | + | chr22:26052841–26053085 | 244 | 91980 |
| ADRBK2 | chr22:25960861–26125258 | + | chr22:26097050–26097320 | 270 | 136189 |
| ARNTL | chr11:13277734–13387266 | + | chr11:13283216–13283586 | 370 | 5482 |
| ARNTL | chr11:13277734–13387266 | + | chr11:13298458–13299341 | 883 | 20724 |
| ARNTL | chr11:13277734–13387266 | + | chr11:13310624–13311040 | 416 | 32890 |
| ARNTL | chr11:13277734–13387266 | + | chr11:13312905–13313275 | 370 | 35171 |
| ARNTL | chr11:13277734–13387266 | + | chr11:13351630–13351900 | 270 | 73896 |
| ARNTL | chr11:13277734–13387266 | + | chr11:13361071–13361575 | 504 | 83337 |
| ARNTL | chr11:13277734–13387266 | + | chr11:13364729–13364973 | 244 | 86995 |
| ARNTL | chr11:13277734–13387266 | + | chr11:13365612–13366116 | 504 | 87878 |
| BCR | chr22:23522552–23660224 | + | chr22:23525622–23525892 | 270 | 3070 |
| BCR | chr22:23522552–23660224 | + | chr22:23546679–23546949 | 270 | 24127 |
| BCR | chr22:23522552–23660224 | + | chr22:23562075–23562399 | 324 | 39523 |
| BCR | chr22:23522552–23660224 | + | chr22:23566052–23566322 | 270 | 43500 |
| BCR | chr22:23522552–23660224 | + | chr22:23591914–23592184 | 270 | 69362 |
| BCR | chr22:23522552–23660224 | + | chr22:23624008–23624332 | 324 | 101456 |
| BCR | chr22:23522552–23660224 | + | chr22:23647903–23648174 | 271 | 125351 |
| BCR | chr22:23522552–23660224 | + | chr22:23651156–23651400 | 244 | 128604 |
| BDNF | chr11:27676442–27743605 | − | chr11:27667673–27667943 | 270 | −8499 |
| BDNF | chr11:27676442–27743605 | − | chr11:27671454–27671716 | 262 | −4726 |
| BDNF | chr11:27676442–27743605 | − | chr11:27680076–27680346 | 270 | 63259 |
| BDNF | chr11:27676442–27743605 | − | chr11:27721240–27721484 | 244 | 22121 |
| BDNF | chr11:27676442–27743605 | − | chr11:27723005–27723329 | 324 | 20276 |
| BDNF | chr11:27676442–27743605 | − | chr11:27739843–27740167 | 324 | 3438 |
| BDNF | chr11:27676442–27743605 | − | chr11:27740692–27741122 | 430 | 2483 |
| BDNF | chr11:27676442–27743605 | − | chr11:27741795–27742502 | 707 | 1103 |
| BDNF | chr11:27676442–27743605 | − | chr11:27742701–27743071 | 370 | 534 |
| BDNF | chr11:27676442–27743605 | − | chr11:27743607–27744258 | 651 | +2 |
| BDNF | chr11:27676442–27743605 | − | chr11:27744566–27744890 | 324 | +961 |
| CASP8 | chr2:202098166–202152434 | + | chr2:202096900–202097280 | 380 | −1266 |
| CASP8 | chr2:202098166–202152434 | + | chr2:202098061–202098441 | 380 | −105 |
| CASP8 | chr2:202098166–202152434 | + | chr2:202122713–202123093 | 380 | 24547 |
| CRH | chr8:67088612–67090846 | − | chr8:67089099–67090281 | 1182 | 565 |
| CRH | chr8:67088612–67090846 | − | chr8:67090287–67090659 | 372 | 187 |
| CRH | chr8:67088612–67090846 | − | chr8:67090956–67091280 | 324 | +110 |
| CRH | chr8:67088612–67090846 | − | chr8:67091915–67092285 | 370 | +1069 |
| CRH | chr8:67088612–67090846 | − | chr8:67098519–67098889 | 370 | +7673 |
| DISC1 | chr1:231762561–232177019 | + | chr1:231795960–231796330 | 370 | 33399 |
| DISC1 | chr1:231762561–232177019 | + | chr1:231814930–231815200 | 270 | 52369 |
| DISC1 | chr1:231762561–232177019 | + | chr1:231925791–231926295 | 504 | 163230 |
| DISC1 | chr1:231762561–232177019 | + | chr1:231963016–231963520 | 504 | 200455 |
| DISC1 | chr1:231762561–232177019 | + | chr1:231964053–231964309 | 256 | 201492 |
| DISC1 | chr1:231762561–232177019 | + | chr1:232067746–232067990 | 244 | 305185 |
| DISC1 | chr1:231762561–232177019 | + | chr1:232148522–232148892 | 370 | 385961 |
| DRD3 | chr3:113847557–113918254 | − | chr3:113871366–113871690 | 324 | 46564 |
| DRD3 | chr3:113847557–113918254 | − | chr3:113874262–113874642 | 380 | 43612 |
| DRD3 | chr3:113847557–113918254 | − | chr3:113897607–113898013 | 406 | 20241 |
| DRD3 | chr3:113847557–113918254 | − | chr3:113898443–113898813 | 370 | 19441 |
| DRD4 | chr11:637305–640705 | + | chr11:640330–640654 | 324 | 3025 |
| DTNBP1 | chr6:15523032–15663289 | − | chr6:15552018–15552288 | 270 | 111001 |
| DTNBP1 | chr6:15523032–15663289 | − | chr6:15621994–15622224 | 230 | 41065 |
| DTNBP1 | chr6:15523032–15663289 | − | chr6:15662506–15662830 | 324 | 459 |
| FKBP5 | chr6:35541362–35696397 | − | chr6:35656504–35656848 | 344 | 39549 |
| FKBP5 | chr6:35541362–35696397 | − | chr6:35687515–35687759 | 244 | 8638 |
| FKBP5 | chr6:35541362–35696397 | − | chr6:35695292–35695562 | 270 | 835 |
| FKBP5 | chr6:35541362–35696397 | − | chr6:35695873–35696103 | 230 | 294 |
| FKBP5 | chr6:35541362–35696397 | − | chr6:35699743–35700105 | 362 | −3346 |
| FOS | chr14:75745481–75748937 | + | chr14:75743830–75744074 | 244 | −1651 |
| FOS | chr14:75745481–75748937 | + | chr14:75745296–75745800 | 504 | −185 |
| GABRA5 | chr15:27111866–27194357 | + | chr15:27110041–27110545 | 504 | −1825 |
| GABRA5 | chr15:27111866–27194357 | + | chr15:27111625–27112129 | 504 | −241 |
| GAD1 | chr2:171673200–171717659 | + | chr2:171670663–171671101 | 438 | −2537 |
| GAD1 | chr2:171673200–171717659 | + | chr2:171671290–171671546 | 256 | −1910 |
| GAD1 | chr2:171673200–171717659 | + | chr2:171672190–171672567 | 377 | −1010 |
| GAD1 | chr2:171673200–171717659 | + | chr2:171679546–171679776 | 230 | 6346 |
| GAD1 | chr2:171673200–171717659 | + | chr2:171701873–171702253 | 380 | 28673 |
| GRIK3 | chr1:37261128–37499844 | − | chr1:37269486–37269856 | 370 | 229988 |
| GRIK3 | chr1:37261128–37499844 | − | chr1:37301874–37302144 | 270 | 197700 |
| GRIK3 | chr1:37261128–37499844 | − | chr1:37329834–37330078 | 244 | 169766 |
| GRIK3 | chr1:37261128–37499844 | − | chr1:37331752–37332256 | 504 | 167588 |
| GRIK3 | chr1:37261128–37499844 | − | chr1:37332540–37332784 | 244 | 167060 |
| GRIK3 | chr1:37261128–37499844 | − | chr1:37388506–37388750 | 244 | 111094 |
| GRIK3 | chr1:37261128–37499844 | − | chr1:37389788–37390253 | 465 | 109591 |
| GRIK3 | chr1:37261128–37499844 | − | chr1:37411488–37411732 | 244 | 88112 |
| GRIK3 | chr1:37261128–37499844 | − | chr1:37431706–37432281 | 575 | 67563 |
| GRIK3 | chr1:37261128–37499844 | − | chr1:37486267–37486654 | 387 | 13190 |
| GRIK3 | chr1:37261128–37499844 | − | chr1:37494616–37494860 | 244 | 4984 |
| GRIK3 | chr1:37261128–37499844 | − | chr1:37504779–37505043 | 264 | −4935 |
| GRM3 | chr7:86273230–86494192 | + | chr7:86290343–86290599 | 256 | 17113 |
| GRM3 | chr7:86273230–86494192 | + | chr7:86322086–86322456 | 370 | 48856 |
| GRM3 | chr7:86273230–86494192 | + | chr7:86476174–86476554 | 380 | 202944 |
| GRM3 | chr7:86273230–86494192 | + | chr7:86497476–86497720 | 244 | +3284 |
| JUN | chr1:59246463–59249785 | − | chr1:59249472–59249885 | 413 | −100 |
| MAG | chr19:35782989–35820133 | + | chr19:35796870–35797100 | 230 | 13881 |
| MAG | chr19:35782989–35820133 | + | chr19:35809956–35810280 | 324 | 26967 |
| MAOA | chrX:43515409–43606068 | + | – | – | – |
| MLC1 | chr22:50497820–50523781 | − | – | – | – |
| MOBP | chr3:39543557–39567857 | + | chr3:39540121–39540386 | 265 | −3436 |
| MOBP | chr3:39543557–39567857 | + | chr3:39558349–39558719 | 370 | 14792 |
| MOBP | chr3:39543557–39567857 | + | chr3:39574318–39574698 | 380 | +6461 |
| MTHFR | chr1:11845787–11866160 | − | chr1:11845214–11845454 | 240 | +573 |
| MTHFR | chr1:11845787–11866160 | − | chr1:11850982–11851306 | 324 | 14854 |
| MTHFR | chr1:11845787–11866160 | − | chr1:11856563–11856793 | 230 | 9367 |
| MTHFR | chr1:11845787–11866160 | − | chr1:11857775–11857960 | 185 | 8200 |
| MTHFR | chr1:11845787–11866160 | − | chr1:11858618–11858699 | 81 | 7461 |
| MTHFR | chr1:11845787–11866160 | − | chr1:11863764–11864034 | 270 | 2126 |
| MTHFR | chr1:11845787–11866160 | − | chr1:11865502–11865882 | 380 | 278 |
| MTHFR | chr1:11845787–11866160 | − | chr1:11866038–11866425 | 387 | −265 |
| NAPG | chr18:10525873–10552766 | + | chr18:10525815–10526242 | 427 | −58 |
| NCAM1 | chr11:112831969–113092626 | + | chr11:112831909–112832179 | 270 | −60 |
| NCAM1 | chr11:112831969–113092626 | + | chr11:112977293–112977549 | 256 | 145324 |
| NCAM1 | chr11:112831969–113092626 | + | chr11:113008930–113009200 | 270 | 176961 |
| NCAM1 | chr11:112831969–113092626 | + | chr11:113011853–113012123 | 270 | 179884 |
| NCAM1 | chr11:112831969–113092626 | + | chr11:113023160–113023664 | 504 | 191191 |
| NCAM1 | chr11:112831969–113092626 | + | chr11:113074175–113074445 | 270 | 242206 |
| NR1D1 | chr17:38249037–38256973 | − | chr17:38244467–38244847 | 380 | +4570 |
| NR1D1 | chr17:38249037–38256973 | − | chr17:38254215–38254595 | 380 | 2378 |
| NR1D1 | chr17:38249037–38256973 | − | chr17:38255228–38255666 | 438 | 1307 |
| NR1D1 | chr17:38249037–38256973 | − | chr17:38256685–38257094 | 409 | −121 |
| NR1D1 | chr17:38249037–38256973 | − | chr17:38257324–38257828 | 504 | −351 |
| NR1D1 | chr17:38249037–38256973 | − | chr17:38264445–38264769 | 324 | −7472 |
| NR3C1 | chr5:142657496–142783254 | − | chr5:142784785–142785394 | 609 | −2140 |
| NRG1 | chr8:31496911–32622558 | + | chr8:31499444–31499814 | 370 | 2533 |
| NRG1 | chr8:31496911–32622558 | + | chr8:31612484–31612740 | 256 | 115573 |
| NRG1 | chr8:31496911–32622558 | + | chr8:31629195–31629565 | 370 | 132284 |
| NRG1 | chr8:31496911–32622558 | + | chr8:31652781–31653242 | 461 | 155870 |
| NRG1 | chr8:31496911–32622558 | + | chr8:31691004–31691508 | 504 | 194093 |
| NRG1 | chr8:31496911–32622558 | + | chr8:31817830–31818086 | 256 | 320919 |
| NRG1 | chr8:31496911–32622558 | + | chr8:31896212–31896582 | 370 | 399301 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32084240–32084744 | 504 | 587329 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32122327–32122831 | 504 | 625416 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32189091–32189595 | 504 | 692180 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32191794–32192298 | 504 | 694883 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32200953–32201685 | 732 | 704042 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32245491–32245735 | 244 | 748580 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32276508–32276752 | 244 | 779597 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32284202–32284706 | 504 | 787291 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32392615–32392985 | 370 | 895704 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32405958–32406282 | 324 | 909047 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32406492–32406892 | 400 | 909581 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32411341–32411845 | 504 | 914430 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32487206–32487506 | 300 | 990295 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32488853–32489109 | 256 | 991942 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32503654–32504024 | 370 | 1006743 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32546371–32546746 | 375 | 1049460 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32572641–32573145 | 504 | 1075730 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32581201–32581705 | 504 | 1084290 |
| NRG1 | chr8:31496911–32622558 | + | chr8:32582687–32583047 | 360 | 1085776 |
| PAFAH1B3 | chr19:42801185–42806952 | − | chr19:42806435–42806939 | 504 | −13 |
| PER3 | chr1:7844714–7905237 | + | ~14 Kb upstream of 5׳UTR | – | – |
| PDLIM5 | chr4:95373038–95509370 | + | chr4:95372903–95373283 | 380 | −135 |
| PDLIM5 | chr4:95373038–95509370 | + | chr4:95406777–95407007 | 230 | 33739 |
| PDLIM5 | chr4:95373038–95509370 | + | chr4:95418920–95419164 | 244 | 45882 |
| PDLIM5 | chr4:95373038–95509370 | + | chr4:95455973–95456203 | 230 | 82935 |
| PDLIM5 | chr4:95373038–95509370 | + | chr4:95456267–95456511 | 244 | 83229 |
| PDLIM5 | chr4:95373038–95509370 | + | chr4:95471601–95471831 | 230 | 98563 |
| PDLIM5 | chr4:95373038–95509370 | + | chr4:95499407–95499663 | 256 | 126369 |
| RELN | chr7:103112231–103629963 | − | chr7:103127865–103128245 | 380 | 501718 |
| RELN | chr7:103112231–103629963 | − | chr7:103276613–103276992 | 379 | 352971 |
| RELN | chr7:103112231–103629963 | − | chr7:103297949–103298179 | 230 | 331784 |
| RELN | chr7:103112231–103629963 | − | chr7:103301028–103301258 | 230 | 328705 |
| RELN | chr7:103112231–103629963 | − | chr7:103354935–103355205 | 270 | 274758 |
| RELN | chr7:103112231–103629963 | − | chr7:103438111–103438481 | 370 | 191482 |
| RELN | chr7:103112231–103629963 | − | chr7:103451010–103451107 | 97 | 178856 |
| RELN | chr7:103112231–103629963 | − | chr7:103484281–103484449 | 168 | 145514 |
| RELN | chr7:103112231–103629963 | − | chr7:103491745–103492249 | 504 | 137714 |
| RELN | chr7:103112231–103629963 | − | chr7:103559848–103560078 | 230 | 69885 |
| RELN | chr7:103112231–103629963 | − | chr7:103580845–103581215 | 370 | 48748 |
| RELN | chr7:103112231–103629963 | − | chr7:103636658–103636861 | 203 | −6898 |
| RFX4 | chr12:106976685–107156582 | + | chr12:106975282–106975646 | 364 | −1403 |
| RFX4 | chr12:106976685–107156582 | + | chr12:106975776–106976119 | 343 | −909 |
| RFX4 | chr12:106976685–107156582 | + | chr12:107147300–107147544 | 244 | 170615 |
| RGS4 | chr1:163038396–163046592 | + | chr1:163039054–163039341 | 287 | 658 |
| SLC12A6 | chr15:34522197–34630265 | − | chr15:34516950–34517512 | 562 | +5247 |
| SLC12A6 | chr15:34522197–34630265 | − | chr15:34610582–34611086 | 504 | 19179 |
| SLC12A6 | chr15:34522197–34630265 | − | chr15:34630069–34630393 | 324 | −128 |
| SLC12A6 | chr15:34522197–34630265 | − | chr15:34634991–34635543 | 552 | −4726 |
| SLC6A2 | chr16:55689542–55737700 | + | chr16:55686047–55686317 | 270 | −3495 |
| SLC6A2 | chr16:55689542–55737700 | + | chr16:55689638–55689908 | 270 | 96 |
| SLC6A2 | chr16:55689542–55737700 | + | chr16:55690575–55690845 | 270 | 1033 |
| SLC6A2 | chr16:55689542–55737700 | + | chr16:55693927–55694197 | 270 | 4385 |
| SLC6A2 | chr16:55689542–55737700 | + | chr16:55695818–55696088 | 270 | 6276 |
| SLC6A2 | chr16:55689542–55737700 | + | chr16:55696686–55696956 | 270 | 7144 |
| SLC6A2 | chr16:55689542–55737700 | + | chr16:55744402–55744761 | 359 | +7061 |
| SLC6A2 | chr16:55689542–55737700 | + | chr16:55746277–55746521 | 244 | +8821 |
| SLC6A4 | chr17:28523378–28562954 | − | – | – | – |
| SULT1A1 | chr16:28616908–28634907 | − | chr16:28621167–28621407 | 240 | 13500 |
| TF | chr3:133419211–133497850 | + | chr3:133461483–133461863 | 380 | 42272 |
| TF | chr3:133419211–133497850 | + | chr3:133465027–133465407 | 380 | 45816 |
| TF | chr3:133419211–133497850 | + | chr3:133472690–133472920 | 230 | 53479 |
| TIMELESS | chr12:56810157–56843200 | − | chr12:56811537–56811907 | 370 | 31293 |
| TIMELESS | chr12:56810157–56843200 | − | chr12:56842752–56843263 | 511 | −63 |
| TPH2 | chr12:72332626–72426221 | + | chr12:72332400–72332889 | 489 | −226 |
| TPH2 | chr12:72332626–72426221 | + | chr12:72374868–72375372 | 504 | 42242 |
| TPH2 | chr12:72332626–72426221 | + | chr12:72410895–72411165 | 270 | 78269 |
| XBP1 | chr22:29190548–29196560 | − | chr22:29196394–29196960 | 566 | −400 |
| XBP1 | chr22:29190548–29196560 | − | chr22:29198252–29198482 | 230 | −1922 |
NRSF binding sites over top 10 affected genes across all drug treatments from Transcription Factor ChIP-seq from ENCODE version 4. Bold font indicates genes significantly affected by drug challenge. Negative and positive values under Position represent the location of the NRSF site upstream of the gene transcriptional start site and downstream of the 3׳UTR, respectively. Values not assigned +/− represent binding sites within the gene sequence. For genes with multiple transcripts, binding site positions are with respect to the largest isoform.