Fig. 1.

Experimental and simulated temporal variability in repolarization. (A) Experimental data showing repeated 1 Hz stimulations of isolated guinea pig ventricular myocytes from the apex and the base of the heart. Simulated reproductions of the data using four parameterizations of the SDE model are shown below each set of experimental data. Modified from Walmsley et al. (2010). (B) Poincaré plots of the original experimental data (red) and those generated from the guinea pig apex cell 1 parameter set are shown at pacing cycle lengths of 1000 ms, 400 ms, 300 ms, 260 ms, and 220 ms for the stochastic (black) and deterministic (green dot) versions of the model. (For interpretation of the references to colour in this figure caption, the reader is referred to the web version of this paper.)