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. Author manuscript; available in PMC: 2014 Dec 19.
Published in final edited form as: Autoimmunity. 2009 Nov;42(7):596–604. doi: 10.1080/08916930903002495

Figure 1.

Figure 1

Innate and adaptive immune responses lead to vascular damage in GCA. Tissue injury of the vascular wall in GCA is the cumulative effect of a cascade of immune events. Early steps relate to the functioning of the innate immune system with danger signals triggering artery-intrinsic DC. Induction of adaptive immune responses creates granulomatous infiltrates with tissue-injurious potential. The vascular wall responds with a remodeling program that is maladaptive and endangers the supply of blood and nutrients to dependent organs.