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Vascular DC shape the arrangement and composition of T-cell responses in the arterial wall. Triggering of wall-embedded DC by different TLR ligands results in distinct architectures of vessel wall inflammation. TLR4 ligands induce the release of CCL20, the preferred recruitment of CCR6þ T cells and the establishment of wall-penetrating inflammation. TLR5 agonists facilitate T-cell recruitment with T cells clustering in the adventitia, assembling a perivascular infiltrate.
