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. Author manuscript; available in PMC: 2014 Dec 19.
Published in final edited form as: J Neurosci Res. 2008 Sep;86(12):2763–2773. doi: 10.1002/jnr.21721

Fig. 8. VQI(I/V) motif mediates tau association with hsc70 and hsp70 in neuronal cells.

Fig. 8

Transfected SH-SY5Y human neuroblastoma cell lines, stably expressing 3R wild-type or ΔI308/ΔV309 (mutant) tau, were subjected to thermal conditioning to increase hsp70 protein levels. Tau immunoprecipitates were analyzed by probing Western blots for hsc70 (lanes 1–6), hsp70 (lanes 13–18) or tau (lanes 7–12). Hsp70 (arrow) migrated slightly faster than hsc70 (arrowhead). Similar to hsc70, little or no hsp70 co-immunoprecipitated with the mutant tau.