Table 4.

BDNF Polymorphisms Associated with Response to Antidepressant Treatment with Desipramine

SNP (Type^*)	Chr Position	Genotype	Intent-to-treat analysis^{^}				Complete-case analysis^{^}
SNP (Type^*)	Chr Position	Genotype	N	Mean ± SD	β (95% CI)	p	N	Mean ± SD	β (95% CI)	p
rs7124442 (3′ UTR)	27633617	CC/CT	43	37.97 ± 30.35	14.88 (2.99, 26.77)	0.02	28	50.17 ± 25.58	14.6 (3.09, 26.11)	0.02
rs7124442 (3′ UTR)		TT	58	48.17 ± 30.77	14.88 (2.99, 26.77)	0.02	40	60.88 ± 22.58	14.6 (3.09, 26.11)	0.02
rs11030102 (Intronic)	27638172	GG/GC	33	35.64 ± 30.60	15.72 (3.14, 28.31)	0.02	21	46.64 ± 27.50	15.09 (3.08, 27.11)	0.02
rs11030102 (Intronic)		CC	65	49.45 ± 30.04	15.72 (3.14, 28.31)	0.02	47	60.86 ± 21.56	15.09 (3.08, 27.11)	0.02
rs12273539 (Intronic)	27639887	TT/TC	53	47.30 ± 30.89	−13.70 (−25.95, −1.45)	0.03	35	61.13 ± 21.34	−14.16 (−26.1, −2.23)	0.02
rs12273539 (Intronic)		CC	44	36.35 ± 31.42	−13.70 (−25.95, −1.45)	0.03	28	49.66 ± 27.49	−14.16 (−26.1, −2.23)	0.02
rs61888800 (5′ UTR, Intronic)	27678854	TT/TG	33	36.05 ± 30.83	17.12 (4.19, 30.05)	0.01	21	47.28 ± 27.64	18.41 (6.24, 30.57)	0.004
rs61888800 (5′ UTR, Intronic)		GG	60	49.84 ± 31.14	17.12 (4.19, 30.05)	0.01	41	63.84 ± 20.96	18.41 (6.24, 30.57)	0.004
rs56133711 (Intronic)	27679910	AA/AG	28	36.54 ± 29.80	15.52 (2.64, 28.40)	0.02	18	48.57 ± 28.44	14.12 (1.20, 27.04)	0.04
rs56133711 (Intronic)		GG	63	50.16 ± 29.58	15.52 (2.64, 28.40)	0.02	45	61.64 ± 21.44	14.12 (1.20, 27.04)	0.04
rs2030324 (Intronic)	27683491	AA/AG	61	40.35 ± 30.63	12.81 (0.34, 25.29)	0.05	37	52.44 ± 24.80	14.2 (2.78, 25.62)	0.02
rs2030324 (Intronic)		GG	39	48.79 ± 32.27	12.81 (0.34, 25.29)	0.05	29	63.70 ± 21.84	14.2 (2.78, 25.62)	0.02
rs12273363 (Upstream)	27701435	CC/CT	29	34.59 ± 28.61	15.81 (2.54, 29.09)	0.02	19	48.29 ± 24.16	14.28 (1.47, 27.09)	0.03
rs12273363 (Upstream)		TT	71	46.39 ± 31.99	15.81 (2.54, 29.09)	0.02	48	59.44 ± 24.00	14.28 (1.47, 27.09)	0.03
rs7931247 (Upstream)	27703567	TT/TC	63	39.90 ± 30.23	13.2 (0.92, 25.49)	0.04	38	51.72 ± 24.86	14.94 (3.53, 26.35)	0.01
rs7931247 (Upstream)		CC	39	48.79 ± 32.27	13.2 (0.92, 25.49)	0.04	29	63.70 ± 21.84	14.94 (3.53, 26.35)	0.01

Intron-exon boundaries were based on multiple alternative 5′ exons in NCBI AceView Database.

^{^}

Mean: average relative reduction in HAM-D21 score; SD: standard deviation; β: regression coefficient for allele effect based on dominant model after adjusting for gender, age and baseline HAM-D21 score.