Table 3.
Cognitive change from baseline to final study visit.
| Outcome | Mean (SD) Initial Visit | Mean (SD) Final Visit | Estimate (SE) | P-value |
|---|---|---|---|---|
| Global Cognition | 28.1 (1.8) | 27.1 (3.3) | 7.0 | <.0001 |
| Trail Making Test, part Aa | 35.9 (12.8) | 29.8 (12.6) | 8.2 | <.0001 |
| Trail Making Test, part Ba | 14.0 (5.8) | 10.2 (5.5) | 14.1 | <.0001 |
| HVLT-R learningb | 13.2 (5.0) | 14.1 (6.6) | −4.2 | <.0001 |
| HVLT-R recallb | 3.8 (2.6) | 4.9 (3.5) | −7.0 | <.0001 |
| Purdue Pegboard | 52.2 (9.6) | 58.0 (15,4) | −8.7 | <.0001 |
| Brief Test of Attention | 6.6 (2.3) | 6.6 (2.4) | 0.7 | 0.49 |
| Pattern Comparison Test | 24.8 (7.2) | 23.2 (7.7) | 6.5 | <.0001 |
| Clock drawing, command | 8.3 (1.7) | 7.8 (1.9) | 3.9 | 0.01 |
| Clock drawing, copy | 9.2 (1.3) | 9.0 (1.4) | 2.7 | <.0001 |
| Digit Span | 13.3 (3.4) | 14.2 (3.7) | −3.1 | 0.002 |
| Letter fluency | 22.0 (8.3) | 14.6 (5.5) | 22.1 | <.0001 |
| Animal fluency | 13.2 (4.3) | 9.4 (3.1) | 17.7 | <.0001 |
a
Trail Making Test parts A and B were coded as number of connections per minute, with higher values indicating better performance.
b
HVLT-R learning and recall were coded as number of items not recalled, with higher values indicating poorer performance.