Table 5. Associations of SNPs with nominal replication signals with clinical characteristics associated with breast cancer in a pooled set of discovery and replication cohorts.
N-Stage | M-Stage | Estrogen Receptor status (0 = positive, 1 = negative) | T-stage | |||||||||
SNP | OddsRatio | 95% ConfidenceInterval | p-value | Odds Ratio | 95% ConfidenceInterval | p-value | OddsRatio | 95% ConfidenceInterval | p-value | OddsRatio | 95%ConfidenceInterval | p-value |
rs12358475 | 0.88 | 0.78–0.99 | 0.04 | 0.94 | 0.70–1.27 | 0.70 | 1.09 | 0.96–1.24 | 0.16 | 0.96 | 0.85–1.08 | 0.49 |
rs421379 | 1.06 | 0.83–1.35 | 0.65 | 1.25 | 0.93–1.67 | 0.14 | 1.09 | 0.89–1.34 | 0.39 | 0.98 | 0.77–1.25 | 0.88 |
rs1728400 | 1.09 | 0.96–1.22 | 0.17 | 1.30 | 0.99–1.70 | 0.05 | 1.07 | 0.9501.21 | 0.29 | 1.11 | 0.99–1.24 | 0.05 |
N-stage = metastasis to lymph node, M-stage = metastasis stage and T-stage = Tumour stage.