Axial CE CT images with 250 mm2 regions of interest (ROI, red circle) on the liver (a), left kidney (b), right paraspinous muscle (c) and left flank subcutaneous fat (d). These were replicated exactly on the reduced dose series for a given patient and approximated as closely as possible on the standard dose series and across patients. These images were the reduced dose series reconstructed with filtered back projection (RD FBP) in a 63 yr old female pt with BMI of 38.8 and effective diameter of 35.5. SSDE for the reduced dose series was 8.6 mGy, compared to the standard dose series dose of 21.7 mGy, with a dose reduction of approximately 60%.