. 2014 Oct 29;10(4):529–564. doi: 10.1007/s11302-014-9427-2

Table 2.

Expression profiles and functional responses of the purinergic receptor subtypes in different immune cells

Inflammatory cell type	Functional response to purines	P2 receptor subtype (expression profile and/or involvement in functional response)
Neutrophils	Undefined roles	P2Y₁, P2Y₄, P2Y₁₁, P2Y₁₄ and P2X₇
	Calcium mobilization	P2Y₂
	Actin polymerization	P2Y₂
	Primary granule release	P2Y₂
	Chemotaxis	P2Y₂, P2Y₆ and P2X₁
	Reduced cAMP accumulation	P2Y₁₄
	Delay in constitutive neutrophil apoptosis	P2Y₁₁
Macrophages	Undefined roles	P2Y₄, P2Y₆, P2Y₁₁, P2Y₁₂, P2Y₁₃, P2Y₁₄ and P2X₁–P2X₆
	Intracellular calcium increase	P2Y₁, P2Y₂, P2Y₄, P2Y₁₁, P2X₄ and P2X₇
	IL-1β/IL-18 maturation/release via the NLRP3 inflammasome, caspase-1 and cytosolic K⁺ depletion	P2X₇
	Release of cathepins, PGE₂, MMP-9 phosphatidilserine (caspase independent)	P2X₇
	Promoting chemotaxis/phagocytosis	P2Y₂, P2Y₁₂, P2X₁ and P2X₃
	Regulation of autophagy	P2X₄ and P2X₇
	Multinucleated giant cells formation	P2X₇
Dendritic cells	Undefined roles	P2X₁, P2X₄, P2X₅, P2X₇, P2Y₁, P2Y₄, P2Y₆ and P2Y₁₁
	Regulation in cytokine release	P2Y₁₁
	DC maturation	P2Y₁₁, P2Y₁₂ and P2Y₁₄
	Apoptosis	P2X₇
	DC migration	P2Y₂ and P2Y₁₁
Lymphocytes
B and T cells	Undefined roles	P2X₂, P2X₃, P2X₅, P2X₆ and all P2Y
	T cell activation (p38 MAPK activation and IL-2 gene transcription )	P2X₁, P2X₄ and P2X₇
	T cell activation (CD62L shedding)	P2X₇
	cAMP accumulation	P2Y₁₄
	Inhibition of immunosuppressive potential of Tregs	P2X₇
Natural killer cells	Regulation of NK cytoxicity and chemotaxis	P2Y₁₁
Eosinophils	Undefined roles	P2Y₁, P2Y₄, P2Y₆, P2Y₁₁, P2Y₁₄, P2X₁, P2X₄ and P2X₇
	Chemotaxis	P2Y₂
	Release of chemokines and cytokines	P2Y₂, P2X₁, P2X₇ and P2Y₆
Mast cells	Undefined roles	P2X₁, P2X₄, P2X₆, P2X₇, P2Y₁, P2Y₂, P2Y₁₁, P2Y₁₂ and P2Y₁₃
Mast cells	Degranulation	P2Y₁₃ and P2Y₁₄

Reproduced from [550], with permission from Springer