Table 1.
Summary of GLP-1R mRNA, GLP-1 Radioligand Binding, and GLP-1R-ir in the Nonhuman Primate CNS
| Area | Monkey ISH | Monkey ISLB | Monkey IHC (cells) | Monkey IHC (fibers) | Rat ISH | Rat ISLB |
|---|---|---|---|---|---|---|
| Cortex | ||||||
| Prefrontal cortex | − | − | − | − | − | − |
| Parietal cortex | − | − | − | − | − | − |
| Temporal cortex | − | − | − | − | − | − |
| Occipital cortex | − | − | − | − | − | − |
| Forebrain | ||||||
| Hippocampus | + | − | − | − | + | − |
| NAc | ++ | ++ | ++ | ++ | + | ++ |
| Caudate-Putamen | − | − | − | − | + | − |
| Striatum | ++ | ++ | ||||
| Globus pallidus (internal) | + | + | + | + | NA | NA |
| Globus pallidus (external) | − | − | − | − | NA | NA |
| Islands of Calleja | − | +++ | − | − | − | ++ |
| Diagonal Band of Broca | + | + | ++ | ++ | + | ++ |
| Central nucleus of the AMGD | +++ | +++ | ++ | ++++ | − | ++ |
| Medial nucleus of the AMGD | ++ | ++ | + | ++ | − | ++ |
| Bed nucleus of the stria terminalis | ++ | ++ | +++ | +++ | + | + |
| Lateral septum | + | + | ++ | ++ | ++ | +++ |
| Medial septum | + | + | ++ | ++ | + | + |
| Thalamus | ||||||
| Anterodorsal nucleus | − | − | − | − | − | ++ |
| Centromedial nucleus | − | − | − | − | − | ++ |
| Laterodorsal nucleus | − | − | − | − | + | ++ |
| PVN | ++ | + | + | + | ++ | + |
| Posterior nucleus | − | − | − | − | +++ | ++ |
| Zona incerta | − | − | − | − | + | ++ |
| Hypothalamus | ||||||
| POA | + | ++ | ++ | ++ | +++ | + |
| Supraoptic nucleus | +++ | ++ | +++ | +++ | +++ | NA |
| PVN | +++ | +++ | +++ | +++ | ++++ | ++ |
| Lateral hypothalamus | ++ | + | + | + | + | ++ |
| Dorosmedial nucleus | ++ | ++ | ++ | ++ | + | ++ |
| Arcuate nucleus | ++++ | ++++ | ++++ | ++++ | ++++ | +++ |
| Ventromedial nucleus | − | − | − | − | − | + |
| Midbrain | ||||||
| VTA | ++ | ++ | ++ | ++ | ++ | ++ |
| Substantia nigra | + | ++ | ++ | ++ | NA | NA |
| DTg | ++++ | ++++ | ++++ | ++++ | +++ | +++ |
| PAG | + | ++ | + | +++ | +++ | ++ |
| DR | + | ++ | + | ++ | + | ++ |
| Pontine reticular nucleus | + | + | − | ++ | + | ++ |
| Lateral reticular formation | ++ | ++ | ++ | +++ | + | NA |
| LC | + | ++ | + | + | + | NA |
| Cerebellar lobule 9–10 | ++ | ++ | − | +++ | NA | NA |
| Medial cerebellar nuclei | +++ | +++ | +++ | +++ | NA | NA |
| Hindbrain | ||||||
| Parabrachial nucleus | ++ | ++ | ++ | +++ | + | + |
| NTS | ++ | ++++ | ++++ | ++++ | +++ | ++++ |
| AP | ++++ | ++++ | ++++ | ++++ | ++++ | ++++ |
| DMX | + | ++++ | ++ | ++++ | NA | NA |
| A1/C1 area | + | ++ | − | ++ | NA | NA |
| Gi | + | ++ | + | ++ | NA | NA |
| Inferior olivary nucleus | + | ++ | − | + | +++ | +++ |
| Spinal cord | ||||||
| Dorsal horn | − | ++++ | − | ++++ | NA | NA |
Overview of areas in the monkey brain containing GLP-1R mRNA (ISH), GLP-1R binding (ISLB), and GLP-1R-ir (IHC) from low (+) to high (++++) concentrations. To facilitate comparison with the rodent, our data are compared with previously published data in the rat. Rat ISH data from Merchenthaler et al (5). Rat ISLB data from Goke et al (14). NA, data not available.