Cells were cultured from pituitary glands of male Δex3-GRIC or control mice and treated or not with 1nM activin A. After 24 hours, cells were harvested for analysis of Fshb or Lhb mRNA levels by real-time RT-PCR (A), and spent media were collected for analysis of FSH and LH (B). Experiments were performed 3 times, in triplicate. Columns, means of the 3 experimental replicates; error bars, SEM. Columns labeled with different letters were statistically different (P < .05, two-way ANOVA with Tukey's post hoc test).