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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Biomaterials. 2014 Dec 9;0:141–150. doi: 10.1016/j.biomaterials.2014.11.012

Figure 3.

Figure 3

Flow cytometric evaluation of FA-P407-ATV/r and P407-ATV/r in hu-PBL reconstituted NSG mice infected with HIV-1ADA. On day 0, PBS, Free drug or nanoATV/r (a combination of ATV and rRTV) was delivered to PBL–reconstituted NSG mice at doses (A) 100 mg/kg, (B) 50 mg/kg or (C) 10 mg/kg. Mice were then infected with HIV-1ADA on day 1 and sacrificed on day 14. Fluorescence-activated cell sorting analyses show the ratio of human CD4+ to CD8+ T cells among total CD3+ T cells for peripheral blood and spleen from individual mice. Data are means ± SEM and *, **statistically different at P < 0.05 and P < 0.01 by Mann-Whitney U-test.