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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Biomaterials. 2014 Dec 9;0:141–150. doi: 10.1016/j.biomaterials.2014.11.012

Figure 5.

Figure 5

Comparison of antiretroviral activities of FA-P407-ATV/r and P407-ATV/r in hu-PBL reconstituted NSG mice infected with HIV-1ADA. Mice were treated on day 0 with PBS, free drug ATV/r, P407-ATV/r or FA-P407-ATV/r at doses of (A) 100 mg/kg or (B) 50 mg/kg. Mice were then infected with HIV-1ADA on 24 hours later and sacrificed on day 14. Paraffin embedded sections of liver, spleen and lung were probed for HIV-1p24 and HLA-DR. Antiretroviral efficacy was determined by counting the number of HIV-1p24+ cells per section and expressed as percent of HLA-DR+ cells. Data are expressed as mean ± SEM and *, **statistical differences were determined at P < 0.05 and P < 0.01 by the Mann-Whitney U-test.