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. Author manuscript; available in PMC: 2015 Dec 18.
Published in final edited form as: Immunity. 2014 Nov 25;41(6):1052–1063. doi: 10.1016/j.immuni.2014.11.009

Figure 5. IL-17A neutralizing antibody reduces colonic tumor load.

Figure 5

(A–C) 5-month-old CPC-APC mice were injected with isotype control or anti-IL-17A antibodies for 2 weeks at 500 ug/injection/week. (A) Immunostaining of cryosections of colonic tumors. (B) Quantitation of P-p65 (n=10) and Ki-67 (n=6) positive cells in HMF from (A). (C, D) 2-month-old CPC-APC mice were injected weekly with isotype control or anti-IL-17A antibodies and sacrificed at 5 months of age for bright field imaging (C) and analysis of tumor parameters (D, n=6). Data are averages ± S.E.M. * p < 0.05. Scale bar = 100 μm.