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. 2014 Nov 14;15(11):511. doi: 10.1186/s13059-014-0511-2

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© Herman et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Halofuginone short-term induced and long-term selected parasites specifically upregulate intracellular proline concentration. (A,B) Of the 19 proteogenic amino acids assayed from saponin-released purified parasites, only proline concentrations were increased in Dd2 Induced parasites (A) and long-term selected lines HFGRII and HFGRIII (B). The fold increase in amino acid concentration upon induction or selection is expressed as a ratio of induced/selected line measurement over parental Dd2 line measurement. Amino acid levels of saponin-released P. falciparum parasites were quantified from the normalized integrated peak intensity determined by LC-MS. Error bars denote standard deviation.