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. 2014 Nov 30;14:126. doi: 10.1186/s12935-014-0126-4

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© Jia et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Knockdown of SKP2 expression in MCF-7 and MDA-MB-231 cells induced up-regulation of p27 and p21. MCF-7 or MDA-MB-231 cells were transfected with SKP2-SiRNA or negative SiRNA (control-SiRNA) for 24 h or 48 h, (NEG means control group). Down-regulation of SKP2 expression was evaluated by western blotting. A protein level of p21 and p27 in all cells was examined by western blotting. Also shown is a blot for GAPDH as a loading control. The representative data of at least two independent experiments are shown.