TABLE 2.
Frequency and characterization of polymorphisms among natural variants of LT detected among ETEC strains analyzed in this study
| No. | LT variant | Alternative designation | No. (%) of ETEC strains (n = 192) | Amino acid substitution(s) in: |
No. of amino acid replacements |
||
|---|---|---|---|---|---|---|---|
| A subunit | B subunit | A subunit | B subunit | ||||
| 1 | LT1 | 78 (40.6) | 0 | 0 | |||
| 2 | LT2 | 48 (25) | S190L, G196D, K213E, S224T | T75A | 4 | 1 | |
| 3 | LT3 | LT3 + R13H | 6 (3.2) | K213E, R235G | R13H | 2 | 1 |
| 4 | LT7 | 2 (1) | P12S, S190L, G196D, K213E, S224T | T75A | 5 | 1 | |
| 5 | LT8 | 7 (3.6) | T203A, K213E | R13H | 2 | 1 | |
| 6 | LT11 | 7 (3.6) | M37I, T193A, K213E, I232 M | 4 | 0 | ||
| 7 | LT12 | LT12 + R18H | 2 (1) | R18H, M37I | 2 | 0 | |
| 8 | LT13 | 13 (6.8) | R18H, M23I | 2 | 0 | ||
| 9 | LT17 | 4 (2.1) | H27N | 1 | 0 | ||
| 10 | LT18 | 12 (6.3) | G196D | 1 | 0 | ||
| 11 | LT19 | 1 (0.5) | S216T | 1 | 0 | ||
| 12 | LT20 | 3 (1.6) | D170N | 1 | 0 | ||
| 13 | LT21 | 1 (0.5) | H27Y | 1 | 0 | ||
| 14 | LT22 | 1 (0.5) | S190L, T193A, G196D, K213E, S224T | T75A | 5 | 1 | |
| 15 | LT23 | 1 (0.5) | I236V | 1 | 0 | ||
| 16 | LT24 | 2 (1) | V103I | 1 | 0 | ||
| 17 | LT25 | 1 (0.5) | P12S | 1 | 0 | ||
| 18 | LT26 | 1 (0.5) | S228L | 1 | 0 | ||
| 19 | LT27 | 1 (0.5) | P12S, E229V | 2 | 0 | ||
| 20 | LT28 | 1 (0.5) | R237Q | 1 | 0 | ||