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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Gene. 2014 Sep 26;556(1):13–18. doi: 10.1016/j.gene.2014.09.049

Figure 2.

Figure 2

Mod5/TRIT1 compete for DMAPP substrates with essential pathways. Aggregated Mod5 loses its ability to modify tRNAs and thus yeast that contain aggregated-Mod5 draw less DMAPP out the ergosterol pathway and are better able to overcome fluconazole treatment (Benko et al., 2000; Suzuki et al., 2012).