Table 1.
Baseline Demographics, Clinical, Laboratory Data
| Overall (n = 34) | Placebo (n = 17) | N-3 (n = 17) | P-value | |
|---|---|---|---|---|
| Age | 46.8 (11.9) | 47.2 (12) | 46.4 (12.1) | 0.84 |
| BMI | 32.5 (7.3) | 31.6 (6.7) | 33.3 (8.0) | 0.96 |
| Gender | ||||
| Female (%) | 61.8 | 58.8 | 64.7 | 0.98 |
| Ethnicity | ||||
| Caucasian (%) | 97.1 | 94.1 | 100 | 0.92 |
| Other (%) | 2.9 | 5.9 | 0 | |
| Diabetes (%) | 32.4 | 35.3 | 29.4 | 0.88 |
| Obese (%) | 58.8 | 52.9 | 58.8 | 0.91 |
| Metabolic Synd. Criteria | 3.3 (1.2) | 3.3 (1) | 3.2 (1.3) | 0.88 |
| ALT (U/L) | 66.8 (35.7) | 60.8 (40) | 72.8 (30.9) | 0.34 |
| AST (U/L) | 55.6 (39.7) | 45.7 (31.5) | 63.7 (44.7) | 0.21 |
| Fasting glucose (mg/dL) | 110.4 (18.5) | 114.5 (21.3) | 106.3 (14.7) | 0.20 |
| Fasting insulin (μIU/mL) | 22.8 (13.5) | 20.4 (13) | 25.2 (14) | 0.31 |
| HOMA-IR | 6.3 (4.3) | 5.9 (4.8) | 6.6 (3.8) | 0.66 |
| Total cholesterol (mg/dL) | 190.3 (35.0) | 189.2 (29.4) | 191.5 (41) | 0.86 |
| LDL cholesterol (mg/dL) | 120.5 (29.8) | 118.5 (27.7) | 122.6 (32.6) | 0.70 |
| Triglycerides (mg/dL) | 173.4 (75.0) | 190.7 (70.8) | 155 (77.1) | 0.17 |
| Free fatty acids (mmol/L) | 0.856 (0.367) | 0.893 (0.274) | 0.820 (0.448) | 0.57 |
| QUICKI-FFA | 0.316 (0.040) | 0.313 (0.030) | 0.318 (0.050) | 0.73 |
| N6/N3 ratio | 76.0 (24.2) | 82.0 (33.2) | 68.8 (34) | 0.22 |
| Adiponectin (pg/mL) | 5.9 (1.6) | 6.0 (1.7) | 5.9 (1.6) | 0.77 |
| M30 | 870.5 (314.5) | 856.2 (329.8) | 884.8 (307.8) | 0.80 |
| M65 | 1180.5 (1085) | 940.0 (436.3) | 1454.1 (352.7) | 0.20 |
| IGFBP-1 | 20.1 (20.9) | 18.7 (15.8) | 21.4 (25.4) | 0.71 |
| Visceral fat (cm3) | 218.3 (76.7) | 193.9 (82.8) | 242.6 (63.7) | 0.08 |
| MRI Dixon fat (%) | 14.8 (8.8) | 11.3 (6.5) | 18.4 (9.8) | 0.07 |
| Image fat (%) | 19.2 (8.5) | 16.3 (4.8) | 22.1 (10.4) | 0.05 |
| Waist circumference (cm) | 109.2 (11) | 106.8 (13.4) | 111.7 (16.6) | 0.36 |
| Steatosis | 2.0 (0.6) | 1.9 (0.6) | 2.2 (0.6) | 0.11 |
| Inflammation | 2.0 (0.5) | 2.0 (0.6) | 2.0 (0.5) | 0.87 |
| Ballooning | 1.2 (0.6) | 1.1 (0.5) | 1.3 (0.6) | 0.31 |
| NAS | 5.2 (0.9) | 4.9 (0.9) | 5.4 (0.9) | 0.09 |
| Fibrosis | 1.9 (0.9) | 1.6 (0.9) | 2.1 (0.8) | 0.16 |
| Daily fructose intake | 27.4 (16.6) | 19.8 (9.6) | 35.1 (18.8) | 0.01 |
| VO2max | 16.9 (5.8) | 16.7 (4.1) | 17.1 (7.3) | 0.84 |
Values are shown as mean (SD).