Table 3.

The number of product molecules generated during CYP3A4 inhibition optimization

Molecule	Generated	Kept	Hits	Effectiveness
Permethrin	769 (101)	521 (86)	141 (9)	27% (10%)
Hexestrol	446 (39)	109 (11)	57 (8)	52% (73%)
alpha-Naphthoflavone	375 (64)	107 (23)	46 (7)	43% (30%)
Propidium	756 (110)	615 (96)	146 (1)	24% (1%)
Bithionol	103 (18)	39 (2)	19 (1)	49% (50%)
Dequalinium	519 (74)	487 (72)	96 (0)	20% (0%)
Oxiconazole	552 (73)	397 (47)	62 (0)	16% (0%)
Lercanidipine	1073 (148)	1037 (148)	175 (0)	17% (0%)