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. 2014 Dec 13;12:347. doi: 10.1186/s12967-014-0347-2

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© Urbanska et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The amount of cytokines produced by BsAb-IR+ T-cells is dependent on the presence of the CD28 costimulatory domains within the immune receptor construct. Comparison of cytokine production by T-cells transduced with different BsAb-IR constructs. Pooled supernatant from triplicate co-cultures were measured for proinflammatory cytokine secretion by cytokine bead assay. IFNg, IL-2, TNFa, IL-4 and IL-10 cytokine concentrations (pg/ml) were measured from cultures of BsAb-IR-z, BsAb-IR-28z and control GFP transduced T-cells stimulated with 0.1ug of an immobilized anti-BsAb-IR (MOV18) antibody. Representative data from 4 independent assays are shown.