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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Aquat Toxicol. 2014 Nov 26;0:192–201. doi: 10.1016/j.aquatox.2014.11.016

Figure 2.

Figure 2

AHR target sites. A. Functional domain structure of the AHR protein. The location of the targeted exons 2 and 3 in relation to the functional domains is shown as red bars. DBD: DNA-binding domain, LBD: ligand-binding domain, TAD: transcriptional activation domain. B. Schematic representations of the ZFN and CRISPR-Cas target regions in AHR2a and AHR2b loci. Arrows represent the primers used in the PCR amplification of genomic DNA for screening. Surveyor nuclease fragments are shown below the target regions.