Table 1.

Published studies employing gene targeting in non-traditional model species.

Gene-editing approach	Species	Reference
ZFN	Monarch butterfly (Danaus plexippus) Two-spotted cricket (Gryllus bimaculatus) Sea urchin (Hemicentrotus pulcherrimus) Ascidian (Ciona intestinalis) Western clawed frog (Xenopus tropicalis) Yellow catfish (Pelteobagrus fulvidraco) Medaka (Oryzias melastigma) Rainbow trout (Oncorhynchus mykiss)	(Merlin et al., 2013) (Watanabe et al., 2012) (Ochiai et al., 2010) (Kawai et al., 2012) (Young et al., 2011) (Nakajima et al., 2012) (Dong et al., 2011) (Ansai et al., 2012) (Yano et al., 2014)
TALEN	Nematode (Pristionchus pacificus) Marine polycheate (Platyneries dumerilii) Culicine mosquito (Aedes aegypti) Silk worm (Bombyx mori) Sea urchin (Hemicentrotus pulcherrimus) Ascidian (Ciona intestinalis) Western clawed frog (Xenopus tropicalis) Iberian ribbed newts (Pleurodeles waltl) Tilapia (Oreochromis niloticus) Medaka (Oryzias melastigma) Yellow catfish (Pelteobagrus fulvidraco)	(Lo et al., 2013) (Bannister et al., 2014) (Aryan et al., 2013b) (Aryan et al., 2013a) (Ma et al., 2012) (Takasu et al., 2013) (Sajwan et al., 2013) (Wang et al., 2013) (Hosoi et al., 2014) (Treen et al., 2014) (Yoshida et al., 2014) (Ishibashi et al., 2012) (Lei et al., 2012) (Nakajima and Yaoita, 2013) (Liu et al., 2014) (Hayashi et al., 2014) (Li et al., 2013) (Wang and Hong, 2014) (Ansai et al., 2014) (Ansai et al., 2013) (Dong et al., 2011)
CRISPR-Cas9	Western clawed frog (Xenopus tropicalis) Axolotl (Ambystoma mexicanum) Atlantic Salmon (Salmo salar) Tilapia (Oreochromis mossambicus)	(Nakayama et al., 2013) (Guo et al., 2014) (Flowers et al., 2014) (Ji-Feng et al., 2014) (Edvardsen et al., 2014) (Li et al., 2014)