Skip to main content
. Author manuscript; available in PMC: 2014 Dec 21.
Published in final edited form as: Vis Neurosci. 2008 Mar-Apr;25(2):139–153. doi: 10.1017/S0952523808080322

Figure 6. Picrotoxin is more effective than bicuculline at blocking GABA-evoked currents elicited at bipolar cell axon terminals or isolated soma-dendritic regions.

Figure 6

(A) Whole-cell current traces show a decrease in GABA-gated currents observed after bath application of 200μM picrotoxin. (B) Whole cell current traces show lesser decrease in current after bath application of 200μM bicuculline. Vhold= −60mV for (A) and (B). (C) Dissociated bipolar cells displayed similar antagonist sensitivity: picrotoxin decreased GABA-evoked fluorescence responses by ~80%, while bicuculline only partially antagonized the response. Figure conventions for voltage-probe records are the same as described in Figure 2.