Table 1.
Normal Mendelian distribution of offspring at the time of weaning
| Genotype | N | % observed | Expected |
|---|---|---|---|
| miR-206/133b+/+ mdxy/+ | 29 | 13.0% | 12.5% |
| miR-206/133b+/+ mdxy/- | 25 | 11.2% | 12.5% |
| miR-206/133b+/− mdxy/+ | 57 | 25.6% | 25.0% |
| miR-206/133b+/− mdxy/- | 41 | 18.4% | 25.0% |
| miR-206/133b−/− mdxy/+ (a) | 35 | 15.7% | 12.5% |
| miR-206/133b−/− mdxy/- (b) | 36 | 16.1% | 12.5% |
| Total | 223 | 100.0% | 100.0% |
Deletion of the miR-206/133b cluster does not lead to abnormalities in the Mendelian distribution of mutant animals (a) at the time of weaning. Additional mdx mutation of the dystrophin gene does not lead to further lethality in double mutant animals (b). Distribution of male offspring after mating of male miR-206/133b+/− mdxy/+ or miR-206/133b+/− mdx+/+ to female miR-206/133b+/− mdx+/− is presented.