Table 2.
Characteristics of PEP exposures and regimens by event-level crystal methamphetamine use (N=84) compared to no crystal methamphetamine use (N=1,046) and by chronic crystal methamphetamine use compared to no chronic methamphetamine use
| Crystal Meth Use at Time of Exposure | No Crystal Meth Use | P-value | Documented Crystal Meth Use Disorder1 | No Crystal Meth Use Disorder | P-value | Overall | |
|---|---|---|---|---|---|---|---|
| Reason for NPEP access | |||||||
| Unprotected anal sex | 68 (81.0%) | 569 (54.4%) | <0.001 | 110 (74.3%) | 527 (53.7%) | <0.001 | 637 (56.4%) |
| Unprotected oral sex | 3 (3.6%) | 74 (7.1%) | 0.27 | 3 (2.0%) | 74 (7.5%) | 0.008 | 77 (6.8%) |
| Condom failure | 7 (8.3%) | 344 (32.9%) | <0.001 | 25 (16.9%) | 326 (33.2%) | <0.001 | 351 (31.1%) |
| Rape | 3 (3.6%) | 31 (3.0%) | 0.74 | 5 (3.4%) | 29 (3.0%) | 0.80 | 34 (3.0%) |
| Needle Sharing | 5 (6.0%) | 2 (0.2%) | <0.001 | 4 (2.7%) | 3 (0.3%) | 0.007 | 7 (0.6%) |
| HIV status of partner | |||||||
| Known infected – on treatment | 8 (9.5%) | 143 (13.7%) | 20 (13.5%) | 131 (13.3%) | 151 (13.4%) | ||
| Known infected – not on treatment | 2 (2.4%) | 44 (4.2%) | <0.001 | 1 (0.7%) | 45 (4.6%) | <0.001 | 46 (4.1%) |
| Known infected – unknown treatment | 32 (38.1%) | 173 (16.5%) | 51 (34.5%) | 154 (15.7%) | 205 (18.1%) | ||
| Unknown status | 42 (50.0%) | 686 (65.6%) | 76 (51.4%) | 652 (66.4%) | 728 (64.4%) | ||
| Tenofovir-based treatment regimen | 70 (84.3%) | 796 (77.3%) | 0.17 | 120 (82.8%) | 746 (77.1%) | 0.13 | 866 (77.8%) |
| Three-drug regimen | 59 (70.2%) | 476 (45.5%) | <0.001 | 97 (65.5%) | 438 (44.6%) | <0.001 | 535 (47.4%) |
1
Individuals could have had more than one NPEP visits; numbers do not add up to 58 (total number of individuals with a documented crystal methamphetamine use disorder)