Table 4.
Association between documented crystal methamphetamine dependence and crystal meth use in the context of the exposure that led to NPEP visit and NPEP visit-level variables
| Unprotected Anal Intercourse1 | Unprotected Receptive Anal Intercourse1,2 | Known HIV infected partner1 | Three-drug regimen1 | |||||
|---|---|---|---|---|---|---|---|---|
| Bivariate OR (95% CI) | Multivariable aOR (95% CI) | Bivariate OR (95% CI) | Multivariable aOR (95% CI) | Bivariate OR (95% CI) | Multivariable aOR (95% CI) | Bivariate OR (95% CI) | Multivariable aOR (95% CI) | |
| CM use during exposure | 4.00 (1.90 to 8.40) | 3.04 (1.37 to 6.79) | 3.58 (1.90 to 6.78) | 2.98 (1.55 to 5.75) | 1.53 (0.97 to 2.44) | 1.29 (0.77 to 2.15) | 2.40 (1.47 to 3.90) | 2.00 (1.16 to 3.45) |
| CM dependence3 | 2.38 (1.38 to 4.11) | 2.25 (1.23 to 4.12) | 2.66 (1.47 to 4.83) | 1.98 (1.04 to 3.78) | 2.03 (1.31 to 3.14) | 2.26 (1.41 to 3.64) | 2.68 (1.65 to 4.37) | 3.27 (1.94 to 5.50) |
| Age at first PEP visit | 1.00 (1.00 to 1.00) | 1.00 (1.00 to 1.00) | 1.00 (1.00 to 1.00) | 1.00 (1.00 to 1.00) | ||||
| In primary care at Fenway Health | 0.78 (0.55 to 1.10) | 1.23 (0.80 to 1.90) | 1.02 (0.73 to 1.43) | 1.00 (0.72 to 1.40) | ||||
| Any health insurance | 1.09 (0.79 to 1.52) | 0.84 (0.56 to 1.27) | 0.95 (0.70 to 1.30) | 1.02 (0.75 to 1.39) | ||||
| Race/ethnicity | ||||||||
| White/Caucasian | Ref | Ref | Ref | Ref | ||||
| Hispanic/Latino | 0.69 (0.44 to 1.10) | 0.80 (0.43 to 1.47) | 1.30 (0.83 to 2.03) | 1.83 (1.16 to 2.91) | ||||
| African American | 0.89 (0.47 to 1.68) | 0.37 (0.16 to 0.85) | 1.89 (1.03 to 3.46) | 1.36 (0.73 to 2.54) | ||||
| Asian | 0.96 (0.48 to 1.92) | 0.86 (0.38 to 1.94) | 0.54 (0.26 to 1.13) | 0.82 (0.42 to 1.62) | ||||
| Other | 1.21 (0.59 to 2.50) | 0.65 (0.28 to 1.51) | 0.92 (0.47 to 1.81) | 1.48 (0.75 to 2.91) | ||||
| History of homelessness | 0.33 (0.12 to 0.96) | 0.73 (0.16 to 3.31) | 3.11 (1.12 to 8.67) | 2.03 (0.66 to 6.24) | ||||
| History of sex work | 1.55 (0.38 to 6.33) | 1.27 (0.26 to 6.07) | 1.63 (0.56 to 4.75) | 1.20 (0.38 to 3.74) | ||||
| Depression at time of PEP | 1.30 (0.87 to 1.94) | 1.55 (0.98 to 2.44) | 0.70 (0.49 to 1.01) | 1.28 (0.89 to 1.83) | ||||
| Anxiety at time of PEP | 1.45 (0.96 to 2.19) | 1.15 (0.71 to 1.85) | 1.04 (0.71 to 1.51) | 0.89 (0.61 to 1.30) | ||||
| ADHD at time of PEP | 1.82 (1.01 to 3.27) | 1.18 (0.65 to 2.14) | 0.65 (0.39 to 1.10) | 0.90 (0.55 to 1.49) | ||||
| Bipolar I/II at time of PEP | 0.61 (0.28 to 1.31) | 3.01 (0.88 to 10.4) | 1.08 (0.53 to 2.22) | 0.65 (0.31 to 1.36) | ||||
| Year of first NPEP Prescription | 1.03 (1.00 to 1.31) | 0.98 (0.94 to 1.02) | 0.99 (0.96 to 1.03) | 0.90 (0.87 to 0.93) | ||||
Abbreviations: CM: crystal methamphetamine; OR: odds ratio; aOR: adjusted odds ratio; CI: confidence interval; NPEP: non-occupational post-exposure prophylaxis; Italics indicates statistical significance (P<0.05)
1
Logistic generalized estimating equation model
2
Restricted to patients reporting unprotected anal intercourse as the source of their exposure
3
Estimated from a model that does not include CM use during exposure