Table 1.
Sham | IRI + Isotype Antibody | IRI + anti-PD-L1 | IRI + anti-PD-L2 | IRI + Both Antibodies | |
---|---|---|---|---|---|
ATN Score | 0.2 ± 0.1 | 0.7 ± 0.3 | 2.7 ± 0.3** | 2.8 ± 0.2** | 3.7 ± 0.1**,# |
Max ATN Score is 5. Mean ± SEM,
denotes P<0.01 vs. IRI + Isotype;
denotes P<0.01 vs. IRI + anti-PD-L1 and vs. IRI + anti-PD-L2.
ATN: acute tubular necrosis; PD-1: programmed cell death 1; IRI: ischemia reperfusion injury; PD-L1: PD-1 ligand 1; PD-L2: PD-1 ligand 2.