Table 2.
Gene | |||
---|---|---|---|
Group | IL-6 | CXCL1 | ICAM-1 |
Sham | 1 | 1 | 1 |
IRI + isotype antibody | 42 ± 18 | 21 ± 9 | 2 ± 1 |
IRI + anti-PD-L1 | 342 ± 85 | 71 ± 28 | 2.7 ± 0.5 |
IRI + anti-PD-L2 | 530 ± 220 | 89 ± 28 | 3 ± 0.4 |
IRI + both antibodies | 1,853 ± 565* | 147 ± 36* | 4 ± 1* |
For each mRNA, expression level in sham-operated mice were set to 1 and expression in each treatment group is expressed as relative arbitrary units.
denotes P < 0.05 vs. IRI + isotype antibody group within each column.
IRI: ischemia reperfusion injury; PD-L1: programmed cell death 1(PD-1) ligand 1; PD-L2: PD-1 ligand 2; IL-6: interleukin 6; CXCL1: chemokine (C-X-C motif) ligand 1; ICAM-1: Intercellular Adhesion Molecule 1.