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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Immunol. 2014 Nov 26;194(1):158–167. doi: 10.4049/jimmunol.1401238

Fig. 8.

Fig. 8

Homozygous deletion of cMyc substantially rescues lymphopenia and spontaneous activation of Apc-deficient T cells. a–c. cMyc deletion has minimal impact on thymocyte development and T lymphocyte cellularity but reduces CD44 expression in spleen T cells. a. Representative profiles depicting thymocyte development based on distribution of CD4 and CD8 markers. c. Summary data showing the frequencies of CD4 and CD8 T cells, data shown are means and SEM (n=9). d. cMyc deletion reduces CD44 expression. Data shown are means and SEM (n=9) of mean fluorescence intensities, depicting CD44 expression among CD4 and CD8 T cells. d. Summary data on thymocytes subsets among 6–8 weeks old mice with or without deletion of Apc and genes. Data shown are means and SEM (n=9). e. Frequencies of CD4 or CD8 T cell from Ctrl (n=6), cKO (n=2), or, cMyc+/−cKO (n=5), or cMyc−/−cKO (n=3). f. Frequencies of naïve, central memory and effector memory T cells in the spleen from Ctrl (n=6), cKO (n=2), Myc+/− cKO (n=5), or cMyc−/−cKO (n=3) mice.