Table 1.
Allogeneic Transplant | Donor and Recipient HLA Matching Recommendation |
---|---|
Matched Sibling |
6/6 HLA match HLA-A and -B (at intermediate or higher resolution using DNA based typing) HLA-DRB1 (at high resolution using DNA based typing) |
1 Antigen Mismatched Related |
7/8 HLA match HLA-A, -B, -C (at intermediate or higher resolution using DNA based typing) HLA-DRB1 (at high resolution using DNA based typing) |
Haploidentical Related |
≥4/8 HLA match HLA-A, -B, -C (at intermediate or higher resolution using DNA based typing) HLA-DRB1 (at high resolution using DNA based typing) [fewer than 2 mismatches per locus] |
8/8 Matched Unrelated Adult |
8/8 HLA match HLA-A, -B, -C and -DRB1 (at high resolution using DNA based typing) |
7/8 Unrelated Adult |
7/8 HLA match HLA-A, -B, -C and -DRB1 (at high resolution using DNA based typing) [7/8 donor available in most situations, do not recommend ≦6/8] |
Umbilical Cord Blood |
≥4/6 HLA match HLA-A, -B (intermediate resolution or higher using DNA based typing) and -DRB1 (at high resolution using DNA based typing) |