. Author manuscript; available in PMC: 2016 Jan 1.

Published in final edited form as: Biol Blood Marrow Transplant. 2014 Sep 30;21(1):4–7. doi: 10.1016/j.bbmt.2014.09.017

Table 1.

Recommendations for Donor HLA assessment and matching categorization for allogeneic stem cell transplantation clinical trial protocol development.

Allogeneic Transplant	Donor and Recipient HLA Matching Recommendation
Matched Sibling	6/6 HLA match HLA-A and -B (at intermediate or higher resolution using DNA based typing) HLA-DRB1 (at high resolution using DNA based typing)
1 Antigen Mismatched Related	7/8 HLA match HLA-A, -B, -C (at intermediate or higher resolution using DNA based typing) HLA-DRB1 (at high resolution using DNA based typing)
Haploidentical Related	≥4/8 HLA match HLA-A, -B, -C (at intermediate or higher resolution using DNA based typing) HLA-DRB1 (at high resolution using DNA based typing) [fewer than 2 mismatches per locus]
8/8 Matched Unrelated Adult	8/8 HLA match HLA-A, -B, -C and -DRB1 (at high resolution using DNA based typing)
7/8 Unrelated Adult	7/8 HLA match HLA-A, -B, -C and -DRB1 (at high resolution using DNA based typing) [7/8 donor available in most situations, do not recommend ≦6/8]
Umbilical Cord Blood	≥4/6 HLA match HLA-A, -B (intermediate resolution or higher using DNA based typing) and -DRB1 (at high resolution using DNA based typing)