Table III.
Changes in microRNA expression in colon during chronic SIV infection.
|
| ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| miRNA ID | Chronic SIV (n=12) | Uninfected Controls (n=4) | Fold Change |
Adjusted p value |
||||||||||||||
|
| ||||||||||||||||||
| HB31 | HB48 | GK31 | GA19 | GH25 | FT11 | DV42 | CP47 | HI68 | FE53 | HG45 | HG58 | EL66 | EH70 | EH80 | FK25 | |||
|
| ||||||||||||||||||
| hsa-miR-181-a* | 24.69 | 23.93 | 24.36 | 24.71 | 24.12 | 24.72 | 24.90 | 25.04 | 25.62 | 24.53 | 24.18 | 24.98 | 23.91 | 23.99 | 23.72 | 24.73 | −1.5 | 0.0027 |
| hsa-miR-628-5p | 25.93 | 25.04 | 25.40 | 25.51 | 24.78 | 24.97 | 25.08 | 25.09 | 25.21 | 24.99 | 24.17 | 25.18 | 24.10 | 24.37 | 24.12 | 25.10 | −1.6 | 0.0027 |
| hsa-miR-378 | 25.03 | 24.87 | 25.34 | 25.27 | 24.65 | 25.70 | 25.27 | 25.76 | 26.11 | 24.71 | 25.07 | 25.46 | 24.93 | 24.87 | 24.95 | 25.83 | −1.2 | 0.0174 |
| hsa-miR-424 | 25.92 | 25.16 | 25.54 | 25.32 | 25.13 | 25.27 | 25.97 | 25.92 | 26.52 | 25.18 | 26.09 | 25.92 | 26.07 | 26.06 | 25.84 | 26.94 | 1.4 | 0.0174 |
| hsa-miR-425* | 25.22 | 24.29 | 24.98 | 25.06 | 25.19 | 25.41 | 25.44 | 25.38 | 25.91 | 24.68 | 24.96 | 25.13 | 24.44 | 24.57 | 24.24 | 24.97 | −1.5 | 0.0174 |
| hsa-miR-454* | 29.52 | 28.81 | 29.09 | 29.78 | 29.25 | 29.79 | 29.77 | 29.31 | 29.51 | 29.21 | 29.02 | 29.39 | 28.23 | 28.60 | 28.42 | 28.97 | −1.8 | 0.0174 |
| hsa-miR-223* | 25.99 | 24.89 | 25.66 | 25.48 | 25.57 | 24.65 | 25.35 | 26.13 | 26.65 | 26.33 | 26.53 | 26.75 | 26.54 | 27.23 | 26.67 | 28.97 | 2.7 | 0.019 |
| hsa-miR-24-2* | 25.36 | 24.79 | 25.31 | 24.98 | 25.04 | 24.75 | 24.92 | 25.58 | 25.33 | 24.98 | 24.65 | 25.22 | 24.51 | 24.78 | 24.40 | 25.18 | −1.3 | 0.019 |
| hsa-miR-520c-3p | 32.61 | 29.79 | 32.98 | 31.59 | 31.06 | 31.12 | 31.94 | 32.16 | 31.29 | 31.80 | 31.35 | 31.20 | 30.51 | 30.43 | 30.33 | 31.20 | −1.8 | 0.019 |
| hsa-miR-34a | 21.44 | 20.92 | 20.74 | 20.39 | 19.43 | 19.67 | 20.32 | 21.32 | 21.14 | 20.82 | 19.96 | 21.01 | 21.76 | 21.97 | 20.97 | 22.16 | 2.2 | 0.0306 |
|
| ||||||||||||||||||
| hsa-miR-34a* | 24.17 | 23.40 | 23.32 | 22.79 | 22.21 | 23.14 | 23.90 | 24.83 | 24.38 | 24.37 | 23.53 | 24.67 | 24.99 | 25.56 | 24.60 | 25.11 | 2.6 | 0.0515 |
| hsa-let-7b | 18.06 | 17.44 | 17.62 | 17.68 | 17.00 | 17.77 | 17.98 | 18.00 | 18.51 | 17.24 | 17.51 | 17.87 | 17.98 | 18.21 | 17.72 | 18.68 | 1.3 | 0.0578 |
| hsa-miR-193b* | 27.03 | 26.74 | 26.67 | 26.42 | 25.97 | 26.56 | 27.79 | 28.64 | 28.21 | 28.00 | 26.18 | 28.62 | 27.80 | 28.45 | 28.01 | 29.03 | 2.3 | 0.0589 |
| hsa-miR-146b-5p | 16.11 | 15.98 | 16.81 | 15.35 | 15.29 | 14.79 | 15.72 | 16.44 | 16.67 | 16.20 | 16.47 | 16.59 | 17.21 | 17.05 | 16.23 | 18.16 | 2.1 | 0.0719 |
| hsa-miR-30d | 20.05 | 20.23 | 20.70 | 20.38 | 20.08 | 20.48 | 20.40 | 21.02 | 20.71 | 19.94 | 19.81 | 20.76 | 19.73 | 19.90 | 19.86 | 20.68 | −1.3 | 0.0758 |
| hsa-miR-744* | 26.22 | 25.74 | 25.97 | 26.25 | 25.91 | 27.28 | 26.71 | 26.78 | 27.15 | 25.89 | 25.96 | 26.54 | 25.72 | 25.56 | 25.53 | 26.51 | −1.5 | 0.0796 |
| hsa-miR-18a | 20.89 | 20.28 | 20.64 | 20.25 | 20.09 | 20.69 | 21.24 | 20.44 | 20.70 | 21.05 | 21.14 | 21.00 | 20.87 | 21.18 | 20.79 | 21.97 | 1.4 | 0.0825 |
| hsa-miR-21 | 15.76 | 15.79 | 16.05 | 14.98 | 14.68 | 14.42 | 15.07 | 15.45 | 15.93 | 15.35 | 15.60 | 16.25 | 15.91 | 15.98 | 15.70 | 16.66 | 1.6 | 0.0825 |
| hsa-miR-422a | 24.87 | 24.01 | 24.74 | 24.78 | 24.01 | 24.30 | 23.57 | 24.44 | 24.92 | 23.44 | 23.89 | 23.80 | 23.43 | 23.23 | 22.88 | 24.08 | −1.8 | 0.0825 |
| hsa-miR-656 | 26.98 | 25.27 | 26.07 | 26.86 | 26.39 | 25.95 | 25.89 | 25.98 | 26.35 | 25.02 | 25.63 | 25.58 | 24.64 | 24.96 | 24.64 | 26.02 | −1.9 | 0.0831 |
| hsa-miR-22* | 23.08 | 22.78 | 23.40 | 23.33 | 23.07 | 22.48 | 23.64 | 23.54 | 23.13 | 23.15 | 22.37 | 23.33 | 23.32 | 23.39 | 23.42 | 24.53 | 1.4 | 0.0845 |
| hsa-miR-30c | 15.71 | 14.74 | 14.86 | 14.83 | 14.55 | 14.76 | 14.88 | 15.15 | 15.57 | 14.49 | 14.55 | 14.92 | 14.51 | 14.55 | 14.17 | 15.17 | −1.3 | 0.0947 |
| hsa-miR-129-3p | 26.03 | 26.55 | 25.28 | 25.31 | 26.12 | 25.96 | 26.07 | 25.54 | 26.79 | 24.73 | 24.34 | 24.95 | 24.48 | 25.00 | 24.19 | 25.34 | −1.7 | 0.095 |
|
| ||||||||||||||||||
The table shows raw CT and fold change for all differentially expressed (adjusted p<0.05, above the bar) and miRNAs that showed a tendency to be statistically significant (p<0.1, below the bar) after applying multiple comparisons correction (Benjamini-Hochberg adjusted p values for false discovery rate) in the colon of twelve chronic SIV-infected macaques.