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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Immunol. 2014 Nov 26;194(1):142–150. doi: 10.4049/jimmunol.1401777

Figure 7. Tryptase and thrombin alter SAP’s IC50.

Figure 7

PBMC were co-incubated with the indicated concentrations of SAP and 12.5 ng/ml (A) trypsin, (B) tryptase, (C) thrombin, or 10 µM (D) PAR-1 agonist or (E) PAR-2 agonist. After 5 days, fibrocytes were counted as in Figure 1. In A-E, the lower curve is SAP alone. Values are mean ± SEM, n=6. * indicates p < .05, ** p < .01, and *** p < .001 compared to the no-protease or no-agonist control (Mann-Whitney test).